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7013 POSTER Multicenter phase II study of chemo-immunotherapy in the treatment of metastatic melanoma

โœ Scribed by Recchia, F.; Candeloro, G.; Necozione, S.; Fumagalli, L.; Rea, S.

Book ID
122636150
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
56 KB
Volume
5
Category
Article
ISSN
1359-6349

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Difluoromethylornithine (DFMO) is an irreversible enzyme-activated inhibitor of ornithine decarboxylase, a key enzyme in polyamine synthesis. We have screened for potential anti-cancer activity of DFMO using a clonogenic assay, which suggested that melanoma might have sensitivity to this agent. Acco