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7-Oxo-prostacyclin affects the electrogenic Na+K+ pump in mouse diaphragm fibers

✍ Scribed by Tania Stankovičová; Hana Zemková; Attila Ziegelhöffer; František Vyskočil


Book ID
115890061
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
435 KB
Volume
276
Category
Article
ISSN
0014-2999

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It is demonstrated a fast and significant depression in the sarcolemmal (Na,K)-ATPase activity that occurs as early as 25 sec after the onset of Ca2+ depletion, and participates in the development of Ca(2+)-paradox in the rat heart. Pretreatment of the animals with 7-oxo-prostacyclin (PGI2) 24-48 h