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7. Gene delivery and biodistribution in the brain and spinal cord following intrathecal administration of adeno-associated virus serotype 5 vector

✍ Scribed by Lalitha Belur; Carolyn Fairbanks; Lucy Vulchanova; Kelly Podetz-Pedersen; Walter Low; R. Scott McIvor


Book ID
116988192
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
56 KB
Volume
93
Category
Article
ISSN
1096-7192

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✍ Naotaka Iwamoto; Atsushi Watanabe; Motoko Yamamoto; Noriko Miyake; Toshiyuki Kur πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 383 KB

## Abstract ## Background The success of gene therapy for inherited neurodegenerative diseases such as metachromatic leukodystrophy (MLD) depends on the development of efficient gene delivery throughout the brain guarded by the blood–brain barrier and achieves distribution of the deficient enzyme