6p21 rearrangements in uterine leiomyomas targeting HMGA1
✍ Scribed by Maliheh Hashemi Nezhad; Norbert Drieschner; Sabrina Helms; Anke Meyer; Mahboobeh Tadayyon; Markus Klemke; Gazanfer Belge; Sabine Bartnitzke; Käte Burchardt; Christiane Frantzen; Ernst Heinrich Schmidt; Jörn Bullerdiek
- Book ID
- 119211574
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 567 KB
- Volume
- 203
- Category
- Article
- ISSN
- 0165-4608
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Two uterine leiomyomas showing involvement of bands I p36 and 2p24 are reported. These rearrangements may indicate a new hot-spot for chromosome changes in this neoplasia, I p36, and confirm the existence of a specific subgroup in leiomyomas, t( 1;2)(p36;p24).
## Abstract Pathogenetically, uterine leiomyomas (ULs) can be interpreted as the result of a monoclonal abnormal proliferation of myometrial cells. Oncogene‐induced senescence (OIS) is a frequent phenomenon in premalignant lesions that leads to a growth arrest mainly by the activation of two potent
Specific chromosomal abnormalities of chromosomal region 6p21.3 have been described in subsets of many benign mesenchymal tumors. In the presented study, we investigated a series of 36 such cases by FISH, and Southern blot analyses for HMGIY rearrangements. FISH results revealed that the chromosomal