690 Moderate alcohol intoxication increases TNF-α and causes hepatic apoptosis in obese mice

Alcohol increases tumor necrosis factor

Alcohol increases tumor necrosis factor α and decreases nuclear factor-κb to activate hepatic apoptosis in genetically obese mice

✍ Marie-Anne Robin; Christine Demeilliers; Angéla Sutton; Valérie Paradis; Carolin 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 643 KB

Both obesity and alcohol can cause oxidative stress, cytokine induction, and steatohepatitis. To determine the consequences of their combination, we compared the hepatic effects of moderate ethanol binges in lean and obese ob/ob mice. Mice received water or ethanol (2.5 g/kg) by gastric intubation d