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69 An antibody to an amino-terminal domain of presenilin-1 immunostains neurofibrillary tangles in Alzheimer's disease

โœ Scribed by Dennis W. Dickson; Wan-Kyng Liu; Shu-Hui Yen


Book ID
117413812
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
138 KB
Volume
17
Category
Article
ISSN
0197-4580

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Both N-terminal and C-terminal fragments
โœ De-Hua Chui; Keiro Shirotani; Hiroshi Tanahashi; Haruhiko Akiyama; Kazuharu Ozaw ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 684 KB

Presenilin 1 (PS1) is a causative gene for chromosome 14-linked familial Alzheimer's disease. The gene product is known to be cleaved into N-terminal fragments (PS1-N) and C-terminal fragments (PS1-C). To understand the pathophysiological role of PS1, we conducted immunohistochemical studies using a