[684] INHIBITION OF C282Y HFE INDUCED JNK ACTIVATION IS PROTECTIVE AGAINST APOPTOSIS IN AN IN VITRO C282Y HFE TRANSFECTED HEK293 CELLS

Expression of hereditary hemochromatosis

Expression of hereditary hemochromatosis C282Y HFE protein in HEK293 cells activates specific endoplasmic reticulum stress responses

✍ Matthew W Lawless; Arun K Mankan; Mary White; Michael J O'Dwyer; Suzanne Norris 📂 Article 📅 2007 🏛 BioMed Central 🌐 English ⚖ 516 KB

## Background Hereditary Hemochromatosis (HH) is a genetic disease associated with iron overload, in which individuals homozygous for the mutant C282Y __HFE__ associated allele are at risk for the development of a range of disorders particularly liver disease. Conformational diseases are a class of