678 AMP-ACTIVATED PROTEIN KINASE (AMPK) IS REQUIRED FOR G1/S PROGRESSION DURING LIVER REGENERATION

The second phase activation of protein k

The second phase activation of protein kinase C δ at late G1 is required for DNA synthesis in serum-induced cell cycle progression

✍ Koichi Kitamura; Keiko Mizuno; Akiko Etoh; Yoshiko Akita; Akitomo Miyamoto; Kei 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 381 KB

## Abstract **Background:** Cell lines that stably over‐express protein kinase C (PKC) δ frequently show a decrease in growth rate and saturation density, leading to the hypothesis that PKCδ has a negative effect on cell proliferation. However, the mode of PKCδ activation, the cell cycle stage requ