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676 Prognostic value of cytosolic thymidine kinase activity as a marker of proliferation in breast cancer

✍ Scribed by S. Ramain; Ib.J. Christensen; O. Chinot; I. Balslev; C. Rose; P.M. Martin; S.M. Thorpe

Book ID
116167423
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
158 KB
Volume
31
Category
Article
ISSN
0959-8049

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Prognostic value of cytosolic thymidine
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Thymidine kinase (TK) is involved in DNA synthesis by the salvage pathway. In this study, thymidine kinase (TK) was determined in routinely prepared cytosols of primary tumors from 290 breast-cancer patients. Enzyme activity was measured using a radioenzymatic method optimized for detection of the f

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Background. Cathepsin D is a lysosomal protease overexpressed and abnormally secreted in most breast cancer cells. Several retrospective clinical studies have shown that cathepsin D is an independent prognostic factor in breast cancer that is associated with a higher risk of recurrence and a shorter