6536 POSTER CYP3A5 polymorphism and NSCLC – a role for genetic variation as a protective factor in lung cancer susceptibility

Polymorphisms in the human CYP1A1 gene a

Polymorphisms in the human CYP1A1 gene as susceptibility factors for lung cancer: exon-7 mutation (4889 A to G), and a T to C mutation in the 3?-flanking region

✍ Drakoulis, N. ;Cascorbi, I. ;Brockm�ller, J. ;Gross, C.R. ;Roots, I. 📂 Article 📅 1994 🏛 Springer-Verlag 🌐 English ⚖ 940 KB

Genetic differences in the metabolism of carcinogens may codetermine individual predisposition to cancer. Cytochrome P-4501A1 (CYP1A1) metabolically activates precarcinogens in cigarette smoke, such as benzo(a)pyrene, which is also an inducer of CYP1A1. Two point mutations have been reported, ml in