65-103 - Estimation of plasma clozapine concentration by analyses of heart rate variation

Effect of altered AGP plasma binding on

Effect of altered AGP plasma binding on heart rate changes by S(−)-propranolol in rats using mechanism-based estimations of in vivo receptor affinity (KB,vivo)

✍ T.J. van Steeg; E.H.J. Krekels; J. Freijer; M. Danhof; E.C.M. de Lange 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 203 KB

In contrast to the impact of plasma protein binding on pharmacokinetics, no quantitative in vivo information is available on its impact on pharmacodynamics. The pharmacokinetic-pharmacodynamic relationship of the model drug S(À)-propranolol was evaluated using mechanism-based estimations of in vivo