## Abstract Most patients with hepatitis B e antigen (HBeAg)βnegative chronic hepatitis B have variants of the hepatitis B virus (HBV) that include mutations in the precore or core promoter regions of the HBV genome. The aim of this study was to investigate the patterns of precore and core promoter
645 HEPATITIS B E ANTIGEN-NEGATIVE MUTATIONS IN THE PRECORE AND CORE PROMOTER REGIONS IN KOREA
β Scribed by J.W. Choi; H.Y. Chang; J.K. Kim; J.Y. Park; D.Y. Kim; Y.H. Paik; K.S. Lee; B.S. Moon; K.H. Han; C.Y. Chon; Y.M. Moon; S.H. Ahn
- Book ID
- 117376571
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 56 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0168-8278
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## Abstract The evolution of precore stop codon mutation (A1896) and dinucleotide mutation (T1762/A1764) in the basic core promoter (BCP) of hepatitis B virus (HBV) genome during transient seroconversion and seroreversion of hepatitis B e antigen (HBeAg) remains unclarified. Five HBeAgβpositive HBV
Mutations in the core promoter and precore regions are frequently found in hepatitis B e antigen (HBeAg)-negative patients, but precore stop codon mutation is restricted to hepatitis B virus (HBV) genotypes that have T at nucleotide 1858. The aims of this study were to determine the role of core pro