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634 EFFECT OF VARDENAFIL ON RHOA/RHO KINASE SIGNALING IN VIVO (SHR RATS) AND CELL CULTURES OF HUMAN BLADDER SMOOTH MUSCLE

✍ Scribed by M. Gacci; G. Vittori; S. Giancane; A. Morelli; S. Filippi; P. Sandner; B. Fibbi; A.K. Chavelmane; E. Silvestrini; E. Sarchielli; L. Vignozzi; G. Vannelli; M. Carini; M. Maggi


Book ID
119621360
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
105 KB
Volume
9
Category
Article
ISSN
1569-9056

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## Abstract ## Aims To investigate the concentration and activity of RhoA in detrusor and urothelium, as well as the effects of a Rho‐kinase inhibitor, Y‐27632 {(+)‐(R)‐trans‐4‐(1‐aminoethyl)‐N‐(4‐pyridyl) cyclohexanecarboxamide dihydrochloride}, on contraction of the pig urinary bladder. ## Meth