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618 Breast cancer resistance protein (BCRP) expression, function and promoter methylation in multiple myeloma: potential mechanism of drug resistance

✍ Scribed by J.G. Turner


Book ID
118621800
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
140 KB
Volume
2
Category
Article
ISSN
1359-6349

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## Abstract ## BACKGROUND Breast cancer resistance protein (BCRP) functions as a drug efflux transporter that mediates drug resistance. Topoisomerase I inhibitors, including 7‐ethyl‐10‐hydroxycamptothecin (SN‐38), are substrates effluxed by BCRP. However, it remains unclear whether the overexpress