613 Development of monoclonal antibodies recognizing the active conformation of epidermal growth factor receptor and application for activation-specific measurement in ELISA

Novel monoclonal antibody specific for t

Novel monoclonal antibody specific for the de2-7 epidermal growth factor receptor (EGFR) that also recognizes the EGFR expressed in cells containing amplification of the EGFR gene

✍ Terrance G. Johns; Elisabeth Stockert; Gerd Ritter; Achim A. Jungbluth; H-J. Su 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 592 KB

## Abstract In some respects, the EGFR appears to be an attractive target for tumor‐targeted antibody therapy: it is overexpressed in many types of epithelial tumor and inhibition of signaling often induces an anti‐tumor effect. The use of EGFR specific antibodies, however, may be limited by uptake