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602 POSTER An anti-idiotypic HER2 vaccine can reverse immunological tolerance to HER2 and induce anti-tumor immunity in huHER2 female transgenic mice

✍ Scribed by M.Z. Ladjemi; S. Corgnac; S. Morisseau; B. Robert; C. Mollevi; T. Charès; W. Jacot; A. Pèlegrin; I. Navarro-Teulon

Book ID: 119599758
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 56 KB
Volume: 6
Category: Article
ISSN: 1359-6349
DOI: 10.1016/s1359-6349(08)72536-9

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## Abstract Tumor cells express tumor‐associated antigens (TAAs), which can serve as targets for the immune system. However, the majority of TAAs are overexpressed products of normal cellular genes; as such, self‐tolerance mechanisms have hindered their use for the induction of effective antitumor