✦ LIBER ✦

6-Substituted Pyrrolo[3,4-c]pyrazoles: An Improved Class of CDK2 Inhibitors

✍ Scribed by Maria Gabriella Brasca; Clara Albanese; Raffaella Amici; Dario Ballinari; Luca Corti; Valter Croci; Daniele Fancelli; Francesco Fiorentini; Marcella Nesi; Paolo Orsini; Fabrizio Orzi; Wilma Pastori; Ettore Perrone; Enrico Pesenti; Paolo Pevarello; Federico Riccardi-Sirtori; Fulvia Roletto; Patrick Roussel; Mario Varasi; Anna Vulpetti; Ciro Mercurio

Book ID: 102100589
Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 443 KB
Volume: 2
Category: Article
ISSN: 1860-7179
DOI: 10.1002/cmdc.200600302

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]

3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: A New Class of CDK2 Inhibitors.

✍ Paolo Pevarello; et al. et al. 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 19 KB 👁 1 views

3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]

3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: A new class of CDK2 inhibitors

✍ Paolo Pevarello; Daniele Fancelli; Anna Vulpetti; Raffaella Amici; Manuela Villa 📂 Article 📅 2006 🏛 Elsevier Science 🌐 English ⚖ 333 KB

Optimization of 6,6-dimethyl pyrrolo[3,4

Optimization of 6,6-dimethyl pyrrolo[3,4-c]pyrazoles: Identification of PHA-793887, a potent CDK inhibitor suitable for intravenous dosing

✍ Maria Gabriella Brasca; Clara Albanese; Rachele Alzani; Raffaella Amici; Nilla A 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 540 KB

Synthesis of substituted 2,4,5,6-tetrahy

Synthesis of substituted 2,4,5,6-tetrahydrocyclopenta[c]pyrazoles and 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles by intramolecular nitrilimine cycloaddition

✍ Winters, Michael P.; Teleha, Christopher A.; Sui, Zhihua 📂 Article 📅 2014 🏛 Elsevier Science 🌐 French ⚖ 648 KB

2-Amino-4-oxo-6-substituted-pyrrolo[2,3-

2-Amino-4-oxo-6-substituted-pyrrolo[2,3-d]pyrimidines as Potential Inhibitors of Thymidylate Synthase.

✍ Aleem Gangjee; Jianming Yu; Roy L. Kisliuk 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 33 KB 👁 1 views

## Abstract For Abstract see ChemInform Abstract in Full Text.

2-amino-4-oxo-6-substituted-pyrrolo[2,3-

2-amino-4-oxo-6-substituted-pyrrolo[2,3-d]pynmidines as potential inhibitors of thymidylate synthase

✍ Aleem Gangjee; Jianming Yu; Roy L. Kisliuk 📂 Article 📅 2002 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 94 KB

## Abstract Classical, antifolate inhibitors of thymidylate synthase often suffer from a number of potential disadvantages when used as antitumor agents. These include impaired uptake due to an alteration of the active transport system required for cellular uptake, as well as the formation of long