Thiopurine methyltransferase deficiency
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Lennard, Lynne; Lewis, Ian J.; Michelagnoli, Maria; Lilleyman, John S.
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Article
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1997
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John Wiley and Sons
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English
โ 76 KB
Daily 6-mercaptopurine (6MP) forms the backbone of continuing chemotherapy for childhood lymphoblastic leukaemia (ALL). A major metabolic route is catalysed by thiopurine methyltransferase (TPMT). TPMT deficiency occurs in 1 in 300 individuals and results in high concentrations of thioguanine nucleo