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6-Hydroxydopamine lesions of the nucleus accumbens attenuate the discriminative stimulus effects of d-amphetamine

✍ Scribed by Steven I. Dworkin; Cindy Bimle


Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
368 KB
Volume
16
Category
Article
ISSN
0272-4391

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## Abstract The neonatal lesion with 6‐hydroxydopamine (6‐OHDA) in rodents induces juvenile hyperactivity and paradoxical hypolocomotor response to psychostimulants, in striking contrast to what is observed when similar lesions are carried out in adults. The early disruption of central dopaminergic