6-Hydrazinonicotinamide Derivatives as Bifunctional Coupling Agents for 99mTc-Labeling of Small Biomolecules

Synthesis and evaluation of two uncharge

Synthesis and evaluation of two uncharged 99mTc-labeled derivatives of thioflavin-T as potential tracer agents for fibrillar brain amyloid

✍ K. Serdons; D. Vanderghinste; M. Van Eeckhoudt; J. Cleynhens; T. de Groot; G. Bo 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 264 KB

## Abstract Thioflavin‐T is a fluorescent dye for __in vitro__ detection of fibrillar amyloid β, a protein found in the brain of patients suffering from Alzheimer's disease. We synthesized and biologically evaluated two uncharged ^99m^Tc‐labeled derivatives of thioflavin‐T. The precursors for label