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6-Benzylidenethiazolo[3,2-b]-1,2,4-triazole-5(6H)-onessubstituted with ibuprofen: synthesis, characterizationand evaluation of anti-inflammatory activity

✍ Scribed by Birsen Tozkoparan; Nesrin Gökhan; Göknur Aktay; Erdem Yeşilada; Mevlüt Ertan

Book ID: 108421968
Publisher: Elsevier Science
Year: 2000
Tongue: French
Weight: 97 KB
Volume: 35
Category: Article
ISSN: 0223-5234
DOI: 10.1016/s0223-5234(00)00157-4

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## Abstract magnified image 3‐Benzyl‐4‐phenyl‐1,2,4‐triazole‐5‐thiol (**1**) was synthesized and used as starting material for preparation of 1,2,4‐triazole bearing substituted thiosemicarbazides moiety (**4a‐d**) in high yields. The thiosemicarbazides **4a‐d** were cyclized in basic medium to giv