✦ LIBER ✦
[6, 7, 10, 11-13C4]-Labelled leukotriene B4 synthesis: standard for mass spectrometry determination and metabolic studies
✍ Scribed by Michel Treilhou; François Couderc
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- French
- Weight
- 125 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0022-2135
- DOI
- 10.1002/jlcr.499
No coin nor oath required. For personal study only.
✦ Synopsis
The mass spectrometry quantification and metabolic studies of leukotriene B 4 (LTB 4 ) in biological fluids require standards labelled with stable isotopes. This paper describes the synthesis of LTB 4 labelled with 13 C in positions 6, 7, 10 and 11 ( % 1). These labelled carbons come from 13 C 2 -acetylene. A labelled LTB 4 is obtained with an isotopic enrichment of 99%.