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6-[18F]Fluoro-l-DOPA metabolism in MPTP-treated monkeys: assessment of tracer methodologies for positron emission tomography

✍ Scribed by William P. Melega; John M. Hoffman; Jay S. Schneider; Michael E. Phelps; Jorge R. Barrio


Book ID
115801364
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
560 KB
Volume
543
Category
Article
ISSN
0006-8993

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Cerebral 6-[18F]fluoro-L-DOPA (FDOPA) me
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We measured 6-[ 18 F]fluoro-L-DOPA (FDOPA) uptake and metabolism in the brain of 4-month-old female pigs (n Ο­ 8) using a high-resolution positron emission tomograph (PET) in 3D mode. The mean net blood-brain clearance of FDOPA (K i D ) to striatum was 0.011 ml g -1 min -1 . Correcting for the elimin