## BACKGROUND. Whereas the embryological development of the human prostate is clearly dependent on steroid 5␣-reductase (5␣-R) type 2 expression, the respective expression of the two known isoforms (types 1 and 2) of 5␣-R in the adult human prostate remains unclear. METHODS. 5␣-R isoform mRNA expr
✦ LIBER ✦
5α-Reductase in Intact DU145 Cells: Evidence for Isozyme I and Evaluation of Novel Inhibitors
✍ Scribed by Wolfgang Reichert; Joachim Jose; Rolf W. Hartmann
- Book ID
- 101386773
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 134 KB
- Volume
- 333
- Category
- Article
- ISSN
- 0365-6233
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## Abstract __N__‐(Dicyclohexyl)acetylpiperidine‐4‐benzylidene‐4‐carboxylic acid (**1**) is an excellent __in vitro__ inhibitor of 5α‐reductase (5αR). Compound **1** showed, however, much lower inhibition activity of 5αR __in vivo__ than __in vitro__, which might be caused by poor membrane permeabi
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