5α-Androst-2-en-17-one
✍ Scribed by Zhang, Datong ;Liu, Jun
- Publisher
- International Union of Crystallography
- Year
- 2007
- Tongue
- English
- Weight
- 750 KB
- Volume
- 63
- Category
- Article
- ISSN
- 1600-5368
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✦ Synopsis
The title compound, C 19 H 28 O, is a useful intermediate for the synthesis of steroidal compounds. The molecular structure has normal bond lengths and angles. The crystal packing is stabilized by van der Waals forces.
📜 SIMILAR VOLUMES
P r e v i o u s l y , we had s u c e s s f u l l y s y n t h e s i z e d [ 5a. 6a-HIandrost-16-en-3-one (3) from 3B-acetoxy-androst-5-en-17-0ne (1) i n f i v e s t e p s 121. After c a t a l y t i c hydrogenation of t h e 5-double bond of (1) w i t h T2 t h e corresponding 17-tosylhydrazone had to
In the title molecule, C 20 H 28 O 3 , ring A has a regular chair conformation, while ring C has a slightly distorted chair conformation. Ring B shows an asymmetric half-chair conformation and ring D is in an envelope conformation. Rings A and B are cis-fused, while rings B and C and rings C and D a
Based on the results obtained in the raceniic series (part I ) , ( -)-17P-hydroxy-des-A-androst-9-en-5-one has been synthesized, starting with (S)-( -)-5-heptanolide. The key step, viz. the condensation of ( S ) -( -)-7-hydroxy-l-nonen-3-one (or its amine adduct) with 2-methyl-cycIopentane-l,3-dione