The total syntheses of three levogyre 3,5-disubstituted indolizidines, (-)-195B, (-)-223AB and (-)-239AB are described. The employed strategy is based on the utilization of the common enantiopure trans 2,5-disubstituted pyrrolidine 3, which is assembled by addition of pent-4-enylcopper to N-acyl imi
(5S)-5-(Trifluoromethyl)pyrrolidin-2-one as a Promising Building Block for Fluoroorganic Chemistry
β Scribed by Andrii V. Bezdudny; Anatoliy N. Alekseenko; Pavel K. Mykhailiuk; Olga V. Manoilenko; Oleg V. Shishkin; Yurii M. Pustovit
- Book ID
- 102174108
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 175 KB
- Volume
- 2011
- Category
- Article
- ISSN
- 1434-193X
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The preparative separation of the enantiomers of the title compound, a versatile chiral building block for the synthesis of unnatural amino acid esters, by high performance liquid chromatography on a chiral stationary phase (CSP), is reported for the first time. The CSP consists of amylose-(3,5-dime
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