5HT1Aagonist, 8-hydroxy-2-(DI-n-propylamino)tetralin (8-OH-DPAT), inhibits non-opioid analgesia in defeated mice: influence of route of administration

✍ Scribed by R. J. Rodgers; J. K. Shepherd

• Publisher: Springer
• Year: 1989
• Tongue: English
• Weight: 323 KB
• Volume: 97
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00442242

✦ Synopsis

Recent studies have suggested that anxiety may be an important factor in the non-opioid analgesic response to defeat in muroid rodents. In the present study, we have examined the influence of the 5-HT~A receptor agonist, 8-OH-DPAT, on basal nociception and defeat analgesia in male DBA/2 mice. Our results show that, while devoid of intrinsic activity on the mouse tail-flick assay, 8-OH-DPAT blocks the analgetic consequences of defeat. A ten-fold potency differential was observed as a function of route of injection, with minimum effective doses of 0.1 and 1.0 rag/ kg for subcutaneous and intraperitoneal administration, respectively. Although further studies are required, these preliminary data support 5-HTIA receptor involvement in the mediation of this form of adaptive pain inhibition.