595 POSTER Insulin-like growth factor-I secreted from prostate stromal cells mediates tumor-stromal cell interactions of prostate cancer

Leucinostatin A inhibits prostate cancer

Leucinostatin A inhibits prostate cancer growth through reduction of insulin-like growth factor-I expression in prostate stromal cells

✍ Manabu Kawada; Hiroyuki Inoue; Shun-Ichi Ohba; Tohru Masuda; Isao Momose; Daishi 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 408 KB

## Abstract Targeting stroma in tumor tissues is an attractive new strategy for cancer treatment. We developed __in vitro__ coculture system, in which the growth of human prostate cancer DU‐145 cells is stimulated by prostate stromal cells (PrSC) through insulin‐like growth factor I (IGF‐I). Using