59 Validation of Therapeutic Targets in K-Ras Driven Lung and Pancreatic Tumors
β Scribed by M. Barbacid
- Book ID
- 117662601
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 65 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0959-8049
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Cationic lipid complexed paclitaxel (EndoTAGβ’β1) is a novel vascular targeting agent for the treatment of cancer. Here, the aim was to investigate intratumoral drug distribution after EndoTAGβ’β1 therapy and analyze the impact of EndoTAGβ’β1 scheduling on antitumoral efficacy. The therape
## Abstract Oncogenic ras is known to inhibit cell death and growth inhibitory genes and activate prosurvival genes. Proapoptotic gene PARβ4, has been found to be downregulated by oncogenic ras. Since pancreatic tumors harbor a high incidence of __Kβras__ point mutations, we hypothesized that oncog