✦ LIBER ✦

59 Understanding the genetic basis of resistance to EGFR targeted therapies to personalize colorectal cancer treatment

✍ Scribed by A. Bardelli

Book ID: 119599825
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 45 KB
Volume: 7
Category: Article
ISSN: 1359-6349
DOI: 10.1016/s1359-6349(09)70062-x

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

The molecular evolution of acquired resi

The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers

✍ Diaz Jr, Luis A.; Williams, Richard T.; Wu, Jian; Kinde, Isaac; Hecht, J. Randol 📂 Article 📅 2012 🏛 Nature Publishing Group 🌐 English ⚖ 333 KB

Activation of signal pathways and the re

Activation of signal pathways and the resistance to anti-EGFR treatment in colorectal cancer

✍ Jiezhong Chen; Xu-Feng Huang; Andrew Katsifis 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 74 KB 👁 1 views

## Abstract Colorectal cancer is the third most common cancer with a 5‐year survival rate of less than 10%. It is caused by alterations of multiple signal pathways which are affected by both genetic and environmental factors. In some cases, EGFR is important in the carcinogenesis of colorectal canc

Combining Targeted Therapies to Enhance

Combining Targeted Therapies to Enhance the Effectiveness of Chemotherapy in Patients with Treatment-Refractory Colorectal Cancer

✍ Cathy Eng 📂 Article 📅 2007 🏛 CIG Media Group, LP. 🌐 English ⚖ 120 KB

Targeting mechanisms of resistance to an

Targeting mechanisms of resistance to anti-EGF receptor therapy in KRAS wild-type colorectal cancer: the path to more personalized medicine

✍ Fakih, Marwan 📂 Article 📅 2013 🏛 Future Medicine 🌐 English ⚖ 452 KB

Epidermal growth factor receptor (EGFR)

Epidermal growth factor receptor (EGFR) as a target in cancer therapy: understanding the role of receptor expression and other molecular determinants that could influence the response to anti-EGFR drugs

✍ F. Ciardiello; Giampaolo Tortora 📂 Article 📅 2003 🏛 Elsevier Science 🌐 English ⚖ 249 KB

Assessment of somatic k-RAS mutations as

Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer

✍ Helena Linardou; Issa J Dahabreh; Dimitra Kanaloupiti; Fotios Siannis; Dimitrios 📂 Article 📅 2008 🏛 The Lancet 🌐 English ⚖ 213 KB