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59 Myelin-phagocytosing macrophages in isolated sciatic and optic nerves reveal a unique reactive phenotype

✍ Scribed by Denise van Rossum; Sören Hilbert; Silke Straßenburg; Uwe-Karsten Hanisch; Wolfgang Brück


Book ID
116398331
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
47 KB
Volume
43
Category
Article
ISSN
1043-4666

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Myelin-phagocytosing macrophages in isol
✍ Denise van Rossum; Sören Hilbert; Silke Straßenburg; Uwe-karsten Hanisch; Wolfga 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 1000 KB

## Abstract Macrophages are key effectors in demyelinating diseases of the central and peripheral nervous system by phagocytosing myelin and releasing immunoregulatory mediators. Here, we report on a distinct, __a priori__ anti‐inflammatory reaction of macrophages phagocytosing myelin upon contact