583: Recurrent BRCA1/2 mutations in Bulgarian patients with hereditary breast and ovarian cancer
β Scribed by Dodova, R.; Mitkova, A.; Dacheva, D.; Taushanova, M.; Valev, S.; Vlahova, A.; Dikov, T.; Timcheva, C.; Christova, S.; Kaneva, R.
- Book ID
- 125798865
- Publisher
- Elsevier Science
- Year
- 2014
- Tongue
- English
- Weight
- 63 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0959-8049
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We report on the screening of the entire BRCA1/BRCA2 coding sequence by SSCP, PTT, and direct sequencing in 68 Italian families with recurrent breast or ovarian cancer. For each investigated proband, the probability of being carrier of a BRCA1/BRCA2 mutation was evaluated using the BRCAPRO software.
## Abstract Among Asian countries, Pakistan has the highest rates of breast and ovarian cancer. To assess the contribution of the __BRCA1__ and __BRCA2__ germ line mutations to these high rates, we conducted the first study of 176 Pakistani breast and ovarian cancer patients, selected on family his