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578 CIRRHOSIS IS ASSOCIATED WITH DEVELOPMENT OF TOLERANCE TO CARDIAC CHRONOTROPIC EFFECT OF ENDOTOXIN IN RATS

โœ Scribed by Z. Haddadian; F. Jazaeri; A.R. Dehpour; A.R. Mani


Book ID
117380790
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
111 KB
Volume
56
Category
Article
ISSN
0168-8278

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Acceleration of the heart rate in response to catecholamines is impaired in cirrhosis. In this study, we tested the hypothesis that increased formation of reactive nitrogen species in biliary cirrhosis causes nitration of cardiac proteins and leads to impaired chronotropic function. Bile duct-ligate