57 MINIMAL-LENGTH SHRNAS ARE POTENT INHIBITORS OF HEPATITIS C VIRUS IN HCV-INFECTED CHIMERIC MICE

HCV796: A selective nonstructural protei

HCV796: A selective nonstructural protein 5B polymerase inhibitor with potent anti-hepatitis C virus activity In Vitro, in mice with chimeric human livers, and in humans infected with hepatitis C virus

✍ Norman M. Kneteman; Anita Y. M. Howe; Tiejun Gao; Jamie Lewis; Dan Pevear; Gary 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 248 KB

## Anti -hepatitis C virus (HCV) drug development has been challenged by a lack of experience with inhibitors inclusive of in vitro, animal model, and clinical study. This manuscript outlines activity and correlation across such a spectrum of models and into clinical trials with a novel selective