**Notes on the Synthesis of Sulfonated Derivatives of 5,6,7,8‐Tetrahydro‐1‐naphthylamine and 5,6,7,8‐Tetrahydro‐2‐naphthylamine** Sulfonation of 5,6,7,8‐tetrahydro‐1‐naphthylamine (**1**) with sulfuric acid gave a mixture of 1‐amino‐5,6,7,8‐tetrahydronaphthalene‐2‐sulfonic acid (**2**), 4‐amino‐5,6
5,6,7,8-Tetrahydro-1(2H)Phthalazinone Derivatives with Potential Pharmacological Activity. Part 1.
✍ Scribed by Florea Dumitrascu; Carmen Irena Mitan; Constantin Draghici; Miron Teodor Caproiu; Andrei Niculae
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 12 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract A new access to 5‐phenyl‐5,6,7,8‐tetrahydro‐1,6‐naphthyridines **25a‐28a** (n=1) and 5‐phenyl‐6,7,8,9‐tetrahydro‐5__H__‐pyrido[3,2‐__c__]azepines **25b‐28b** (n=2) has been developed by first preparing the functional pyridine moiety followed by intramolecular cyclization forming the par
## Abstract Basicity and alkaline hydrolysis of 1,2‐diaryl‐1__H__‐4,5,6,7‐tetrahydro‐1,3‐diazepines 1 are studied. Results are analyzed on the basis of Hammett and Swain‐Lupton constants, finding good structure‐basicity correlation when both, inductive and mesomeric effects, are considered together