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562 POSTER The anti-insulin-like growth factor I receptor antibody EM164 (murine AVE1642) enhances anti-tumor activity of temozolomide against neuroblastoma cell lines and xenografts

✍ Scribed by B. Geoerger; J.F. Brasme; E. Daudigeos; F. Bladt; C. Venot; L. Debussche; P. Vrignaud; G. Vassal

Book ID: 119599718
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 61 KB
Volume: 6
Category: Article
ISSN: 1359-6349
DOI: 10.1016/s1359-6349(08)72496-0

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## Abstract Interaction of insulin‐like growth factor receptor I (IGF‐IR) with its ligands has been reported to induce cell proliferation, transformation and blockade of cell apoptotic functions. IGF‐IR is overexpressed on numerous tumor cell types and its blockade could be of importance for anti‐c