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556 Histone deacetylase inhibitors induce chromatin decondensation by down-regulation of proteins involved in the maintenance of heterochromatin

✍ Scribed by D.C. Marchion; E. Bicaku; A.I. Daud; D.M. Sullivan; P.N. Munster

Book ID
118621738
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
143 KB
Volume
2
Category
Article
ISSN
1359-6349

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## Abstract Inhibition of histone deacetylase (HDAC) is a novel strategy for the treatment of leukemias via restoration of aberrantly silenced genes. In this study, we conducted a detailed analysis of anti‐leukemic effects of an HDAC inhibitor (HDI), depsipeptide (FK228), using myeloid leukemia cel