Ectopic p16ink4 expression enhances CPT-
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Kazuya Fukuoka; Kazuto Nishio; Hisao Fukumoto; Hitoshi Arioka; Hirokazu Kurokawa
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Article
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2000
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John Wiley and Sons
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French
โ 164 KB
A tumor-suppressor gene, p16 INK4 , which is deleted or mutated in tumors, regulates cell-cycle progression through a G 1 -S restriction point by inhibiting CDK4(CDK6)/cyclin-Dmediated phosphorylation of pRb. We have found that ectopic p16 INK4 expression increased cellular sensitivity of human non-