544 Metabolism of chlorpyrifos and diazinon by human liver microsomes
β Scribed by C. Sams; J. Cocker; M.S. Lennard
- Book ID
- 119538313
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 62 KB
- Volume
- 144
- Category
- Article
- ISSN
- 0378-4274
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## Abstract Previous studies have established that chlorpyrifos (CPS), fipronil, and nonane can all be metabolized by human liver microsomes (HLM) and a number of cytochrome P450 (CYP) isoforms. However, metabolic interactions between these three substrates have not been described. In this study th
## Abstract The metabolism of chlorpyrifos (CPS) and chlorpyrifos oxon (CPO) by human hepatocytes and human liver S9 fractions was investigated using LCβMS/MS. Cytochrome P450 (CYP)βdependent and phase IIβrelated products were determined following incubation with CPS and CPO. CYPβrelated products,