Tau protein is a microtubule-associated protein normally expressed in neurons. In Alzheimer's disease (AD) brains, phosphorylated tau accumulates in paired helical filaments which form neurofibrillary tangles in affected neurons; moreover, tau mRNA expression is increased in affected regions of AD b
โฆ LIBER โฆ
539 Delayed increase in tau neuronal gene expression induced by glutamate toxicity in cortical cultures
โ Scribed by F. Esclaire; C. Blanchard; F. Terro; M. Lesort; J. Hugon
- Book ID
- 118578089
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 143 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0197-4580
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## Abstract Neuronal activityโdependent gene transcription is a key feature of longโlasting synaptic strengthening associated with learning and memory, as well as activityโdependent neuroprotection. To comprehensively determine the molecular alterations, we carried out genomeโwide microarray analys