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536 Tau in Alzheimer disease brain is phosphorylated to different degrees at different sites

✍ Scribed by Y. Ikura; T. Kudo; I. Grundke-Iqbal; K. Iqbal; M. Takeda; T. Nishimura


Book ID
117414046
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
286 KB
Volume
17
Category
Article
ISSN
0197-4580

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Phospho-and unphospho-peptides were used to define the essential sequence for a tau epitope, which is recognized by Tau-1 antibody and phosphorylated in Alzheimer's disease (AD). The epitope was mapped within the amino acid residues 192-199 of tau and was phosphorylated by the p34cdc2/p58cyc'i" A pr