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535 FXR-MEDIATED REGULATION OF THE HUMAN HEPATIC BILE ACID UDP-GLUCURONOSYLTRANSFERASE (UGT) 1A3 GENE IN CHOLESTASIS

✍ Scribed by T.J. Erichsen; A. Aehlen; U. Ehmer; T.O. Lankisch; M.P. Manns; C.P. Strassburg


Book ID
117376461
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
51 KB
Volume
48
Category
Article
ISSN
0168-8278

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Glucuronidation, an important bile acid detoxification pathway, is catalyzed by enzymes belonging to the UDP-glucuronosyltransferase (UGT) family. Among UGT enzymes, UGT1A3 is considered the major human enzyme for the hepatic C24-glucuronidation of the primary chenodeoxycholic (CDCA) and secondary l