528 Prostaglandins E1 or E2 enhances the mitogenic effect of prostaglandin F2α in swiss mouse 3T3 cells
✍ Scribed by Luis Jimenez de Asua; Angela Otto
- Book ID
- 116003981
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- English
- Weight
- 119 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0022-4731
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Addition of prostaglandin E1 (PGE1) to quiescent cultures of Swiss 3T3 cells rapidly elevates the intracellular levels of cAMP and increases the activity of adenylate cyclase in particulate fractions of these cells. In the presence of insulin, PGE1 stimulates the reinitiation of DNA synthesis. Both
Lovastatin (LOV), a hydroxy-methylglutaryl-coenzyme A (HMGCoA) reductase competitive inhibitor, blocks epidermal growth factor (EGF)or prostaglandin F , , (PGF,,)-induced mitogenesis in confluent resting Swiss 3T3 cells. This inhibition occurs even in the presence of insulin, which potentiates the a