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520 Secondary chemical reactions mediated by cyclo-oxygenase

✍ Scribed by C. Deby; J. Pincemail; G. Deby-Dupont; P. Braquet; R. Goutier

Book ID
116003973
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
110 KB
Volume
19
Category
Article
ISSN
0022-4731

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✍ M. R. Forwood πŸ“‚ Article πŸ“… 2009 πŸ› American Society for Bone and Mineral Research 🌐 English βš– 576 KB

In vivo, indomethacin blockade of bone formation has been used to illustrate the role of prostaglandins. Indomethacin blocks the constitutive (COX-1) and inducible (COX-2) forms of cyclo-oxygenase, and is therefore nonspecific in its action. To test the hypothesis that COX-2 mediates the bone format