514 Effects of APGW-amid on [Ca2+] in rat pheochromocytoma PC12 cells
β Scribed by Xiao Yan Han; Yuzuru Ito; Ken'ichi Matsunami; Yoshinori Nozawa
- Book ID
- 119523121
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 104 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0168-0102
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The membrane electrical properties of undifferentiated pheochromocytoma cells of the rat (PC12) were studied using both current-and voltage-clamp techniques with the use of low-resistance blunt-tipped micropipettes (patch electrodes). In the presence of tetrodotoxin (TTX, 2-3 ~tM), a spike-like wave
## Background: Suramin inhibits growth of neural crest-derived cells and is used to treat adrenocortical cancer and neuroblastoma in clinical trials. the antiproliferative effect of suramin was evaluated in primary cultures of human pheochromocytoma and the pc12 rat pheochromocytoma cell line in vi