506 Pre-existing mutations at hepatitis B virus polymerase domain may affect response to adefovir dipivoxil therapy in patients with lamivudine-resistant chronic hepatitis B

Novel patterns of amino acid mutations i

Novel patterns of amino acid mutations in the hepatitis B virus polymerase in association with resistance to lamivudine therapy in Japanese patients with chronic hepatitis B

✍ Ogata, Norio; Fujii, Kyuichi; Takigawa, Shingo; Nomoto, Minoru; Ichida, Takafumi 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 160 KB 👁 2 views

Lamivudine is effective in suppressing replication of hepatitis B virus (HBV). However, the emergence of HBV variants resistant to lamivudine is a concern. Lamivudine resistance has been attributed mainly to a substitution of isoleucine or valine for methionine at residue 550 (M550I or M550V) in the