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5-(Pyrrolidin-2-yl)-1H-tetrazole and 5-[(Pyrrolidin-2-yl)methyl]-1H-tetrazole: Proline Surrogates with Increased Potential in Asymmetric Catalysis

✍ Scribed by Michael Limbach

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
199 KB
Volume
3
Category
Article
ISSN
1612-1872

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1-Pentanoyl-N-{[2'-(1H-tetrazol-5-yl)bip
1-Pentanoyl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-pyrrolidine-2-carboxamide: Investigation of Structural Variations
✍ Alessia Catalano; Alessia Carocci; Antonia Di Mola; Claudio Bruno; Patrick M. L. 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 190 KB

## Abstract We recently reported a series of 1‐acyl‐__N__‐(biphenyl‐4‐ylmethyl)pyrrolidine‐2‐carboxamides as AT~1~ receptor ligands. The most potent compound of the series, 1‐pentanoyl‐__N__‐{[2'‐(1__H__‐tetrazol‐5‐yl)biphenyl‐4‐yl]methyl}‐pyrrolidine‐2‐carboxamide, showed an interesting affinity f