✦ LIBER ✦
[5-Leucin]enkephalin-Related Glycoconjugates: Structurally Novel Agents Effective against HIV-1
✍ Scribed by Štefica Horvat; Lidija Varga; Jaroslav Horvat; Andreas Pfützner; Haryadi Suhartono; Helga Rübsamen-Waigmann
- Book ID
- 102257312
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- German
- Weight
- 319 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0018-019X
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✦ Synopsis
Abstract
A series of [Leu^5^]enkephalin‐related glycoconjugates with an ester‐, ether‐, or amide‐type linkage were synthesized and evaluated for antiviral activity against HIV‐1 in a cell‐culture system using peripheral blood lymphocytes. All tested glycoconjugates exhibited a certain antiviral activity which was significantly higher than the activity of the parent peptide compound itself. These results indicate that synthetic glycoconjugates of opioid peptides are good candidates for the development of anti‐HIV agents.