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5-Iodo-2′-deoxyuridine inhibition of Dictyostelium discoideum differentiation and cyclic AMP phosphodiesterase activity

✍ Scribed by Katharine Y. Ku; Barry Goz


Book ID
115774215
Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
422 KB
Volume
27
Category
Article
ISSN
0006-2952

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Treatment of NIH 3T3 cells with adenylate cyclase activator adrenaline (10(-6) M) or cAMP phosphodiesterase inhibitor theophylline (10(-3) M) was shown to lead to intracellular cAMP elevation followed by a 2.0-to 2.5-fold increase in the 2',5'-oligoadenylate synthetase activity. This process was blo