5 INVITED Role of haematopoietic cells in tumour angiogenesis: from discovery to targeted cancer gene therapy

Hypoxia response element-driven cytosine

Hypoxia response element-driven cytosine deaminase/5-fluorocytosine gene therapy system: a highly effective approach to overcome the dynamics of tumour hypoxia and enhance the radiosensitivity of prostate cancer cells in vitro

✍ Laure Marignol; Ruth Foley; Thomas D. Southgate; Mary Coffey; Donal Hollywood; M 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 289 KB

## Abstract ## Background We proposed to exploit hypoxia‐inducible factor (HIF)‐1α overexpression in prostate tumours and use this transcriptional machinery to control the expression of the suicide gene cytosine deaminase (CD) through binding of HIF‐1α to arrangements of hypoxia response elements.